Safety issues and high price of the current anti-amyloid drugs definitely prevent them from being used before Alzheimer's symptoms emerge, but I think there are more barriers. As a field, we need to move in the direction of precision neurology and really understand what types of patients with amyloid buildup in the brain will definitely develop Alzheimer's symptoms and when, and when the optimal time is to intervene with a safe and cheaper pill. There are a lot of human experiments to be done before we can convince millions of people to take a drug that can prevent a disease they may or may not get 10-20 years later.
Songsong CaO
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